EFFECTS OF Terminalia Chebula FRESH FRUIT EXTRACTS IN STREPTOZOTOCIN INDUCED TYPE 2 DIABETIC MODEL RATS

R N Akhand, S Ahmed, A Bhowmik, B Rokeya, M M H Khan and M R Chowdhury
Journal of the Sylhet Agricultural University, Volume 1, Issue 1, 2014, Pages 131-137

Abstract:

The present study was carried out to evaluate the anti-hyperglycemic and anti-hyperlipidemic effects of T. chebula mature fresh fruits (1.25g Kg-1 body weight) in streptozotocin (STZ) induced type 2 diabetic (T2DM) model rats. T2DM was induced in male long-evan rats by a single intraperitoneial (ip) injection of STZ to 48 hours old pups and 3 months later after confirming with an oral glucose tolerance test T2DM rats were selected. The subchronic (28 days) oral administration of 80% ethanol extracts of fresh fruits (P=0.02) of T. chebula significantly reduced serum glucose level and total cholesterol (p=0.001), triglycerides (p=0.016) and LDL-cholesterol (p=0.001) level were significantly decreased compared to water control for fresh fruit extracts. No significant change found with serum insulin and reduced glutathione level. In final day, although statistically insignificant, content of liver glycogen were remarkably higher and the levels of malondialdehyde were notably lower. The study shows that T. chebula fruits improves glycemic status in T2DM rats that probably mediated by an extra-pancreatic mechanism.

Keywords:

Type-2 diabetes, glibenclamide, T. chebula, streptozotocin, oxidative stress


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R N Akhand, S Ahmed, A Bhowmik, B Rokeya, M M H Khan and M R Chowdhury. 2014. EFFECTS OF Terminalia Chebula FRESH FRUIT EXTRACTS IN STREPTOZOTOCIN INDUCED TYPE 2 DIABETIC MODEL RATS, Journal of the Sylhet Agricultural University 1(1): 131-137.