An experiment was conducted at farmer’s field in Panchbibi, Joypurhat during September to December 2016 to evaluate the relative efficacy of homebased botanicals as compared to a synthetic insecticide used by the farmers in controlling cucurbit fruit fly, Bactrocera cucurbitae on bitter gourd. Effectiveness of one synthetic insecticides (Karate 2.5 EC) and four indigenous botanicals (Neem seed extract, Jute seed extract, Mahogani seed extract and Garlic extract) were evaluated to control cucurbit fruit fly on bitter gourd. Fruits got comparatively lower infestation where plants were treated with different plant extracts, while it was minimum in the plants treated with synthetic insecticide. Among the botanicals maximum fruits infestations (39.96-43.82%) were found in the case of garlic extract while minimum damages (19.20-27.47%) were found from jute seed extract that showed about similar effectiveness with the synthetic insecticide viz. Karate 2.5EC (16.24-31.04%). The highest fruit infestation was recorded from untreated control (56.93-58.42%).