The present study was conducted to determine the endoparasitic infestation and their effects on the growth of Channa punctatus from different water bodies in Sylhet during the period from January to May 2013. Six different species of parasites identified from the hosts examined were i). Euclinostomum multicaecum, ii). Allocreadium handiai, iii). Genarchopsis dasus, iv). Isoparorchys hypselobagri, v). Camallanus intestinalus, and vi). Pellisentis ophiocephali. Moderate infestations were found in C. punctatus due to parasites. Prevalence was different in different months. The highest prevalence observed in January (75.00%) and lowest in February (55.56%). Changes in the nature of growth and loss of weight as a result of parasitic infestation were noticed. Accordingly length, weight and condition factors were found greatly affected. Loss of total length was 2.68%. The loss of weight and condition factor was 10.45% and 0.03, respectively. The loss of gonad weight also observed in infested male and female host and it was 5.25% and 3.64%, respectively.