Bio-slurry is a renewable source based organic fertilizer that can improve the nutrient status of soil. An on-farm verification trial of bio-slurry was carried out at farming system research and development site, Jalalpur, Sylhet during rabi season of 2011-12. The aim of the study was to verify the effect of integrated use of bio-slurry along with inorganic fertilization on the performance of radish in agroecological zone (AEZ) 20. The trial was replicated thrice with three treatments viz. T1: soil test basis (STB) inorganic fertilizer dose for high yield goal (HYG), T2: cowdung (CD) bio-slurry @ 5 t ha-1 along with IPNS basis inorganic fertilizer dose for HYG and T3: farmers’ practice i.e. average of 20 farmers’ fertilizer dose. Results revealed that the highest root yield of radish (45.60 t ha-1) was recorded from T2 treatment that was closely followed by T1 treatment (42.60 t ha-1). Increment of radish yield in T2 was 107 and 111% compared to T1 and T3 treatments, respectively. Highest gross return (Tk 3,64,800 ha-1), gross margin (Tk 3,05,550 ha-1) and benefit cost ratio (6.16) were also obtained from the same treatment (T2). But, post harvest chemical analysis of soil indicated that there were no significant changes in soil pH, OM and other nutrients due to application of bio-slurry. However, as bioslurry based crop revenue is more profitable than others and therefore nutrient package N-P-K-S-Zn-B @ 67-44-99-25-2-2 kg ha-1, respectively + CD bio-slurry @ 5 t ha-1 might help provide higher yield of radish as well as sustainable crop management in AEZ 20.